Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-mediated ferroptosis for bone metastases therapy.

ABSTRACT: Bone metastases, as a common disabling and life-threatening complication in the advanced stages of various solid tumors, continue to pose substantial therapeutic challenges due to high drug toxicity and tumor resistance. To overcome the limited efficacy and safety concerns of existing treatments, we developed a novel iron-based photocatalytic nanoplatform (ENCF), guided by second near-infrared (NIR-II) imaging, for the precise treatment of bone metastases. This platform enables in situ photocatalytic release of CO and utilizes exposed iron active sites to synergistically induce ferroptosis through a cascade of oxidative stress, autophagy and iron metabolism disruption under 808 nm laser activation. Mechanistic investigations revealed that the ENCF platform significantly downregulates PCBP2

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12513188 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature