Rethinking the effects of working memory training on executive functions in schizophrenia: A machine learning approach.

ABSTRACT:

Background

Executive dysfunction in schizophrenia profoundly impairs functional outcomes and remains insufficiently addressed by standard pharmacological treatments. While computerized cognitive training offers promise, traditional evaluation methods often fail to capture nuanced improvements along the psychosis-health continuum. This study aims to quantify executive function (EF) profile changes following working memory training and identify robust baseline predictors of treatment response.

Methods

Ninety-four schizophrenia patients were randomized to adaptive N-back training (n = 32), non-adaptive 1-back control (n = 33), or treatment-as-usual (n = 29). EF was assessed across working memory, cognitive flexibility, and inhibitory control domains.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12513198 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature