Probiotic supplementation during pregnancy or infancy for the prevention of allergic rhinitis in infants: A systematic review and meta-analysis of Randomized controlled trials.

ABSTRACT:

Background

Early-life gut microbial colonization is crucial for immune system development, but the efficacy of probiotic interventions during pregnancy or infancy in preventing allergic rhinitis (AR) and atopic sensitization (AS) remains unclear. This systematic review synthesized evidence from randomized controlled trials (RCTs) assessing probiotics for AR and AS prevention.

Methods

Seven English and Chinese databases were systematically searched up to February 13, 2025. Eligible studies were RCTs with clearly defined probiotic interventions and specified AR or AS outcomes. Risk of bias was assessed using the Cochrane tool. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using fixed-effects models.

Results

Fourteen RCTs involving 5886 children were

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC12513199 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature