Spatiotemporal-controlled ultrasound-driven Li-PDA@ZnO nanoparticles promote neural stem cell differentiation synergy with biohydrogel repair spinal cord injury.

ABSTRACT: Neuronal loss following spinal cord injury (SCI) remains a significant barrier to the recovery of neural function. Neural stem cells (NSCs) supplementation offers a promising therapeutic avenue by providing seed cells; however, the differentiation rate of NSCs into neurons is often suboptimal. In this study, lithium was immobilized on the surface of ZnO nanoparticles using a polydopamine coating to synthesize Li-PDA@ZnO nanoparticles. These nanoparticles were designed to induce NSC differentiation into neurons in a spatiotemporal-controlled manner using ultrasound-driven stimulation. Additionally, a biohydrogel system consisting of genipin and collagen was developed to encapsulate NSCs preloaded with endocytosed nanoparticles. The application of ultrasound stimulation to ZnO nanoparticles

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12513234 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature