Liquid biopsy biomarkers in cervical cancer: A systematic review and meta-analysis.

ABSTRACT:

Background/objectives

Liquid biopsy biomarkers are emerging as vital tools for cancer screening and diagnosis, offering a noninvasive and accurate approach to early malignancy detection. This study aimed to assess the diagnostic performance of circulating biomarkers in cervical cancer (CC).

Methods

A comprehensive literature search was conducted across the Cochrane Library, PubMed, SCOPUS, and Web of Science, identifying 130 studies, of which 11 met the inclusion criteria. Data on true and false positives and negatives were extracted to calculate pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratios (DORs), and 95 % confidence intervals (CIs). Study quality and risk of bias were evaluated using the QUADAS-2 tool, while publication bias was assessed via D

SUBMITTER: Njangiru IK 

PROVIDER: S-EPMC12513236 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature