Risk of colorectal cancer after weight loss in the obese: a pooled cohort study.

ABSTRACT:

Background

Though the link between obesity and colorectal cancer (CRC) is convincing, the impact of weight loss after obesity on CRC risk is unknown.

Methods

This pooled study from the Multiethnic Cohort, Nurses' Health Study and Health Professionals Follow-Up Study included adults aged 45-75, with 3+ available body mass index (BMI) measures. The primary analysis included persons of all weights, with exposure (BMI) subjected to group-based trajectory modeling. Time-to-incident CRC was evaluated using accelerated failure time models. A subanalysis evaluated the risk of CRC in persons with obesity who had weight loss, compared to persons with stable obesity.

Results

A total of 193,046 persons were analyzed (median age 49 years, 66% female). Among persons with severe deg

SUBMITTER: Kumar S 

PROVIDER: S-EPMC12513337 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature