Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease.

ABSTRACT:

Background

Treatment strategies for Crohn's disease (CD) suppress diverse inflammatory pathways but many patients remain refractory to treatment. Autologous haematopoietic stem cell transplantation (SCT) is an emerging therapy for medically refractory CD though the mechanisms through which it circumvents refractory pathophysiology are unknown.

Objective

The objective of this study is to understand how the immune system reconstitutes post-SCT and whether SCT may function as a cellular therapy restoring appropriately responsive immune cell populations from haematopoietic stem cells (HSCs).

Design

Adults with CD with active clinical and endoscopic disease who failed available medical therapies were enrolled in a phase II study of SCT for refractory CD (n=19). Blood and i

SUBMITTER: Guisado D 

PROVIDER: S-EPMC12513369 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature