Macrocycle formation-mediated augmentation in reactive oxygen species production.

ABSTRACT: While the synthesis of methylene-bridged fluorescent macrocycles has attracted significant research interest, their ability to generate reactive oxygen species (ROS) remains relatively unexplored. Herein, we present a strategy for constructing multifunctional macrocycles through backbone functionalization and successfully synthesize a new class of [2]terphenyl-extended pillar[6]arenes. Upon incorporating benzothiadiazole, highly fluorescent macrocycles with aggregation-induced emission enhancement characteristics, i.e., [2]terphenyl-benzothiadiazole-extended pillar[6]arenes, were obtained. Subsequent studies on modulating side-chain modifications have revealed distinct singlet oxygen (¹O₂) generation capabilities. Notably, quaternary ammonium-functionalized mac

SUBMITTER: Liu A 

PROVIDER: S-EPMC12513386 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature