NaCl and urea modulate CD8+ T cell survival, renal accumulation, and response to BK virus.

ABSTRACT: BK virus nephropathy is a severe, graft-threatening complication of kidney transplantation that requires an effective T cell response. It typically emerges in the kidney medulla. Elevated osmolyte concentrations that dynamically respond to loop diuretic therapy characterize this environment. Here, BK viremia development in kidney graft recipients negatively correlated with loop diuretic therapy. The association remained significant in multivariable and propensity score-matched analyses. Kidney function was better preserved and CD8+ T cell abundance higher in loop diuretic-exposed allografts. CD8+ T cell densities in healthy human and murine kidney medulla were lower than in cortex and increased upon loop diuretic therapy in mice. As a potential underlying mechanism, kidney medullary NaCl a

SUBMITTER: Falahat P 

PROVIDER: S-EPMC12513482 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature