Heparin improves the mortality of patients with non-pulmonary sepsis-associated ARDS: A MIMIC-IV database analysis based on propensity score matching.

ABSTRACT:

Background

Non-pulmonary sepsis often induces Acute Respiratory Distress Syndrome (ARDS). Dysregulated inflammation and coagulation disorders play important roles in the development of non-pulmonary sepsis-associated ARDS (NPS-ARDS). Heparin, with its potential anticoagulant and anti-inflammatory properties, may be used in the treatment of NPS-ARDS.

Methods

This is a retrospective observational study that uses Structured Query Language (SQL) to extract clinical data of NPS-ARDS patients from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Based on the dosage of heparin, patients were divided into three groups: low-dose heparin treatment group (0-5000u/d), medium-dose heparin treatment group (5000u-10000u/d), and high-dose heparin treatment group (greater

SUBMITTER: Lin J 

PROVIDER: S-EPMC12513587 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature