Predictive value of urinary [TIMP-2]•[IGFBP7] for AKI among sepsis, stroke, and cardiac surgery cohorts: A prospective study.

ABSTRACT:

Background

TIMP-2 and IGFBP7 have shown effectiveness as biomarkers for predicting Acute Kidney Injury (AKI). However, the variations in the predictive capacity of urinary [TIMP-2]• [IGFBP7] for AKI across different etiologies remain unexplored. This study aimed to assess the predictive capability of urinary [TIMP-2]• [IGFBP7] for AKI in three distinct disease cohorts (stroke, sepsis, and cardiac surgery) characterized by differing AKI etiologies.

Methods

This prospective observational study evaluated the predictive value of urinary [TIMP-2]• [IGFBP7] among three cohorts with varying AKI causes. Binary logistic regression was employed to identify AKI's independent risk factors and develop a combined prediction model. The predictive value was assessed using Receiver Operating

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12513614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature