Identification and Validation of Pyroptosis-Associated Gene Signature in Primary Sjogren's Syndrome.

ABSTRACT:

Background

Pyroptosis, a form of programmed cell death, has been implicated in autoimmune diseases (ADs) pathogenesis. However, its role in primary Sjögren's syndrome (pSS) remains unclear. This study aims to identify pyroptosis-related gene (PRG) signatures in pSS.

Methods

Three datasets were obtained from the Gene Expression Omnibus (GEO) database to analyze the gene expression profiles in pSS. Differentially expressed genes (DEGs) were intersected with PRGs to identify pyroptosis-related DEGs (PRDEGs). Functional enrichment was assessed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Key genes were identified using the least absolute shrinkage and selection operator (LASSO) and support vector machine (SVM) analyses. A diagnostic model was cons

SUBMITTER: Dai Y 

PROVIDER: S-EPMC12513781 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature