Synthesis of covalently linked knotted cage frameworks.

ABSTRACT: Interwoven molecular structures underpin the functions of many biomolecules, yet synthesizing artificial topologically complex structures in high yield remains challenging. Here we describe a streamlined, high-yield one-pot synthesis of knotted cage frameworks by using a subcomponent designed to bridge over the faces of a predesigned cage framework. A Zn^II ₄L₃ (where L corresponds to a tritopic pyridyl-imine ligand that coordinates to the metal vertices) open-faced cage framework was employed as the basis for a topologically chiral perplexane, and a Zn^II ₄L₄ tetrahedron was built into a topologically chiral trefoil tetrahedron. Both interwoven architectures can be prepared through one-pot subcomponent self-assembly from a tr

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12513843 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature