Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER.

ABSTRACT: Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain-specific differences following voluntary wheel running exercise training in submaximal and maximal oxygen consumption (VO2), respiratory exchange ratio (RER), and body composition in C57BL/6 and BALB/cJ mice. Male and female mice underwent 4 weeks of voluntary wheel running, followed by sub-maximal and maximal treadmill tests in a metabolic chamber. Results indicate differences in running volume across sexes and strains did not consistently predict changes in physiological adaptations. Female C57BL/6 mice, which ran three times more than males on average, exhibited higher submaximal VO2 compared to their male counter

SUBMITTER: Amiri N 

PROVIDER: S-EPMC12513855 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature