Real-World Characterization of Psychiatric Pharmacogenomic Test Ordering and Clinical Relevance in Adults and Children.

ABSTRACT: Pharmacogenomic (PGx) testing is increasingly utilized to guide psychiatric medication selection and dosing, yet real-world characterizations of test ordering and clinical implications remain understudied. Additionally, the extent to which psychiatry-focused PGx results inform prescribing beyond mental health medications is unclear. This study examined patterns of psychiatry-focused PGx test ordering, the clinical relevance of results among adult and pediatric patients, and implementation challenges within a large health system. Electronic health records (EHRs) of 3383 individuals undergoing psychiatry-focused PGx testing between 2013 and 2023 were analyzed. Test reports, available as unstructured PDFs, required manual curation before merging with clinical data. Demographic characteristics

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12513856 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature