Fluoride exposure and metabolic alterations: a scoping review of metabolomic studies.

ABSTRACT:

Background

Evidence from in-vitro and animal studies suggests that fluoride exposure may alter key metabolic pathways such as amino acid, fatty acid and energy metabolism in different tissues, requiring an understanding of its impact at the molecular level, especially in human populations.

Aim of review

This scoping review aims to systematically map and synthesize the available evidence on metabolic alterations associated with fluoride exposure, specifically focusing on studies employing metabolomic analysis techniques to identify altered metabolites and metabolic pathways at the cellular, tissue, and organ levels.

Key scientific concepts of review

Fluoride exposure has been found to alter a broad range of metabolic pathways, including those involved in energy metabol

SUBMITTER: Tamayo-Cabeza G 

PROVIDER: S-EPMC12513868 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature