Neuroimaging spectrum of myelin oligodendrocyte glycoprotein antibody-associated disease with brain involvement: description of various cerebral syndromes.

ABSTRACT:

Background

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a notable cause of acquired central nervous system inflammatory disorders in children.

Objective

This study aimed to characterize the neuroimaging spectrum of pediatric MOGAD with brain involvement.

Materials and methods

In this retrospective, single-center study, 55 children diagnosed with MOGAD involving the brain between January 2010 and October 2020 were included. Clinical data and neuroimaging-brain and spinal magnetic resonance imaging (MRI) at presentation-were reviewed. Imaging patterns were categorized into six radiologic phenotypes: acute disseminated encephalomyelitis (ADEM), cerebral cortical encephalitis, aseptic meningitis, tumefactive demyelinating lesion, cerebellitis

SUBMITTER: Choi YH 

PROVIDER: S-EPMC12513890 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature