Inflammatory status along the brain-liver axis in animals vulnerable to prenatal stress: sex-related implications for stress-induced comorbidities.

ABSTRACT: The prevalence of mood disorders is constantly increasing, with exposure to stress early in life (ELS) as one of the major risk factors. Recent studies reported that ELS can increase the risk for mental disorders, but also for several cardiometabolic conditions, often in comorbidity. However, biological processes underlying these negative outcomes with a sex dependent effect are still poorly understood. Here, we used the preclinical model of prenatal stress (PNS) mimicking early in life adversities to investigate the presence of an abnormal inflammatory response as a possible mechanism leading to the onset of a vulnerable phenotype for mental and metabolic disorders in the offspring. We showed that adolescent male rats, classified as vulnerable to PNS by a two-step cluster analysis, based

SUBMITTER: D'Aprile I 

PROVIDER: S-EPMC12514046 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature