Dynamic changes in neutrophil activation and metabolic profile during pregnancy are associated with gingival inflammation.

ABSTRACT: Neutrophils are key players in both periodontal and placental immunity, undergoing profound immunometabolic and functional changes during pregnancy. Their excessive activation has been linked to gestational complications. Gingivitis, and even more so periodontitis, the advanced stage of this condition, are chronic inflammatory diseases that frequently worsen during pregnancy and have been associated with adverse outcomes such as fetal growth restriction and placental dysfunction. Although bacterial dissemination and inflammation are thought to mediate this link, the underlying mechanisms remain poorly understood. How neutrophil activation and metabolism evolve throughout pregnancy-and how this relates to the exacerbation of periodontal inflammation-remains largely unexplored. We analyzed t

SUBMITTER: Calo G 

PROVIDER: S-EPMC12514070 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature