Demographic, genetic, neuroimaging, and behavioral correlates of short social responsiveness scale in a large pediatric cohort.

ABSTRACT: The Social Responsiveness Scale (SRS) is an established tool for screening autism. An increasing number of studies have utilized the SRS in the general population as an outcome measure to gain insight into the etiology of autism spectrum disorder (ASD). However, SRS scores have not been well characterized in large pediatric cohorts, particularly in relation to their demographic, genetic, neuroimaging, and comorbidity profiles, or how these patterns compare to those observed in clinically diagnosed ASD. This study included 9788 non-ASD children and 182 autistic children aged 9-11 years from the Adolescent Brain Cognitive Development Study. Generalized linear mixed-effect models were applied to evaluate the associations of short social responsiveness scale (SSRS) with a spectrum of demograph

SUBMITTER: Huang L 

PROVIDER: S-EPMC12514072 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature