Toxicity and mechanistic analysis of di(2-ethylhexyl)phthalate in renal cell carcinoma progression: a systematic study with network toxicology and molecular docking strategies.

ABSTRACT: Millions of tons of unrecycled plastic pollute landfills and oceans, and di(2-ethylhexyl) phthalate (DEHP), a plasticizer classified as a possible carcinogen, is found in many environments, and poses health risks. Renal cell carcinoma (RCC), one of the most prevalent malignancies, accounted for approximately 434,419 new cases and 155,702 deaths in 2022. DEHP can cause developmental dysregulation, reproductive impairments, tumorigenesis, and transgenerational diseases; however, the mechanisms underlying these effects remain unclear. This study aimed to elucidate the toxic targets and molecular mechanisms associated with DEHP exposure and RCC occurrence by integrating network toxicology and molecular docking, utilizing multilevel bioinformatics data. By systematically utilizing diverse datab

SUBMITTER: Ran B 

PROVIDER: S-EPMC12514089 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature