Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer.

ABSTRACT:

Background

Bladder cancer (BC) remains a prevalent malignancy worldwide, with rising incidence rates each year. Despite progress in therapeutic strategies, many patients suffer recurrence or progression, emphasizing the urgent need for novel prognostic biomarkers and therapeutic targets. This research evaluated the prognostic relevance and functional role of Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) in BC.

Methods

We analyzed CPSF3 expression using The Cancer Genome Atlas data and immunohistochemistry on a cohort of 203 BC patients. A nomogram incorporating CPSF3 expression was developed based on CPSF3 expression for prediction of overall survival and disease-free survival. Immune infiltration analyses and transcriptome sequencing were performed to explore un

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12514100 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature