Feasibility and preliminary effects of high-intensity interval training vs. moderate-intensity continuous training on inflammatory and metabolic biomarkers in type 2 diabetes: a pilot randomized controlled trial.

ABSTRACT:

Background

Elevated plasma calprotectin, an inflammatory biomarker, is linked to higher cardiovascular risk in type 2 diabetes (T2DM), suggesting lifestyle interventions like exercise may help regulate it. This pilot study evaluated the feasibility of future full-scale trial for comparing the effect of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) on calprotectin in T2DM patients without cardiovascular disease.

Methods

This open-label, randomized controlled pilot trial was conducted from December 2018 to March 2019 at the Rajaie Cardiovascular Institute, Tehran, Iran. Participants over 18 years of age with T2DM, an HbA1c between 6.5% and 10%, a BMI between 24 and 35 kg/m², and stable medication use for at least four week

SUBMITTER: Alizadeh S 

PROVIDER: S-EPMC12514114 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature