Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids.

ABSTRACT: Autism Spectrum Disorder (ASD) affects 1 percent of the world's population with an increased prevalence of 178 percent since 2000. Although altered synaptic function putatively accounts for many of the abnormalities seen in ASD, the specific molecular mechanisms underlying this disorder remain poorly defined. A growing body of evidence suggests that extracellular vesicles (EVs), specifically exosomes, play a critical role in cellular communication within the brain. While they have been implicated in various types of diseases from cancer to neurodegeneration, their involvement in ASD remains largely unexplored. In this study, we utilized patient-derived cortical organoid models to characterize EVs secreted by human three-dimensional (3D) tissue and defined their cargo. Our study reports, fo

SUBMITTER: Stankovic I 

PROVIDER: S-EPMC12514172 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature