Brain network localization of structural and functional abnormality associated with aggression.

ABSTRACT:

Background

Aggression, while evolutionarily adaptive, becomes maladaptive when it violates social norms and inflicts harm, posing significant societal and clinical challenges. Despite extensive research, the neural mechanisms underlying aggression remain poorly understood due to inconsistent findings and the network localization of aggression remains underexplored.

Methods

This study synthesized findings from 91 neuroimaging studies, including 56 studies on trait aggression (1387 aggressive and 1251 non-aggressive individuals) and 40 studies on elicited aggression (2651 individuals), to identify brain regions implicated in aggression and constructed probability maps of aggression-related brain abnormality networks. We applied functional connectivity network mapping combined

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12514226 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature