<i>Polygonatum sibiricum</i> Delar. ex Redoute: A Potential Functional Food for the Prevention and Treatment of Hyperuricemia.

ABSTRACT: This study evaluated the antihyperuricemic potential of Polygonatum sibiricum (HJ) in both animal and human models. A mouse hyperuricemia (HUA) model was established by administering a high uric acid (UA) diet. The model was then treated with HJ water extract. Serum levels of UA, creatinine (Cr), and urea nitrogen (BUN) were measured using biochemical assay kits. Kidney tissue damage was assessed through H&E and PAS staining. Network pharmacology analysis was employed to elucidate potential mechanisms of action. Untargeted metabolomics analysis was performed on mouse serum using liquid chromatography-mass spectrometry. HJ water extract significantly reduced serum UA levels in HUA mice from 700.82 μmol/L to 236.61 μmol/L (66% decrease). The treatment also markedly lowered serum creat

SUBMITTER: Zhao P 

PROVIDER: S-EPMC12514339 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature