Altered along-the-perivascular space index in functional (psychogenic non-epileptic) seizures: A diffusion tensor imaging study of glymphatic system function.

ABSTRACT:

Objective

The glymphatic system is a critical brain waste-clearance mechanism that facilitates the removal of metabolic byproducts and maintains neural homeostasis. Its dysfunction has been implicated in various neurological disorders; however, its role in functional (psychogenic nonepileptic) seizures (FS/PNES), a functional neurological condition, remains unexplored. This study aimed to indirectly evaluate glymphatic system function using the along the perivascular space (ALPS) index derived from diffusion tensor imaging (DTI) in patients with FS/PNES compared to healthy controls (HCs).

Methods

Twenty-one patients with PNES and 21 HCs underwent DTI scans. Glymphatic system function was assessed using the DTI-ALPS method. The DTI-ALPS index was calculated and analyzed for d

SUBMITTER: Roozbeh M 

PROVIDER: S-EPMC12514360 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature