Neuronal surface and intracellular antibody testing in patients with long-term epilepsy.

ABSTRACT:

Objective

We aimed to investigate the frequency of neuronal surface and intracellular antibodies in individuals with long-term epilepsy and the associated clinical and laboratory characteristics.

Methods

We tested sera from 223 patients with epilepsy without signs of autoimmune encephalitis and 12 patients with epilepsy and a subacute onset of additional neurological symptoms. All had epilepsy lasting at least one year. We compared clinical and laboratory characteristics between those with and without antibodies. Additionally, we assessed the ACES and APE scores, and ONES checklist for identifying patients with antibodies.

Results

Only one of 223 patients with epilepsy and no autoimmune encephalitis signs (0.4%) had antibodies, presenting with drug-resistant mesial te

SUBMITTER: Watanabe N 

PROVIDER: S-EPMC12514361 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature