Enhancing sudden unexpected death in epilepsy (SUDEP) research through development of common data elements.

ABSTRACT:

Objective

Sudden Unexpected Death in Epilepsy (SUDEP) is a fatal complication for individuals living with epilepsy and is associated with significant personal and public burden. While certain neurotransmitters and neuronal pathways have been associated with SUDEP, the exact biological mechanisms are unknown. Preclinical research has been instrumental in providing clues to the underlying pathology but is limited by a lack of standardized methodologies for describing and collecting data. A key outcome of the Basic Science working group of the 2020 SUDEP Coalition Summit was the recognition that the development of standardized tools would greatly enhance SUDEP research. Such a research infrastructure would increase experimental rigor, repeatability, reproducibility, and transparency a

SUBMITTER: Iyengar SS 

PROVIDER: S-EPMC12514369 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature