Enhanced response inhibition in patients with drug-resistant juvenile myoclonic epilepsy: Event-related potentials evidence of excitatory-inhibitory imbalance.

ABSTRACT:

Objective

To investigate the excitatory-inhibitory imbalance in drug-resistant Juvenile Myoclonic Epilepsy (DR-JME) patients using event-related potentials during motor and cognitive tasks.

Methods

Eighteen JME patients and 11 healthy controls performed a visual Go No-Go task while sitting (single-task) and walking (dual-task). EEG signals were analyzed using frequency-domain techniques. Nonparametric tests compared groups and conditions.

Results

JME patients showed worse performance and slower reaction times than healthy controls (p < 0.04). DR-JME patients demonstrated worse performance during Go cues (p = 0.001) but better withdrawal response to No-Go cues (p = 0.03) compared to drug-respondent JME. Significant differences in EEG spectral power were observed, parti

SUBMITTER: Sarah L 

PROVIDER: S-EPMC12514377 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature