Epilepsy and systemic autoimmune diseases: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Objective

Epidemiological data indicates that individuals with epilepsy exhibit an elevated susceptibility to autoimmune disorders, and conversely, those with systemic autoimmune diseases (SAD) demonstrate a heightened predisposition to epilepsy. Although an increasing number of publications support this association, the causal direction remains undetermined. This investigation offers evidence supporting a causal relationship between these conditions through a bidirectional two-sample Mendelian randomization (MR) analysis.

Methods

Bidirectional two-sample MR analyses were performed to investigate the causal relationships and directionality between various epilepsy subtypes and eight SAD. The analysis utilized genome-wide association study (GWAS) summary data for the followin

SUBMITTER: Tian R 

PROVIDER: S-EPMC12514391 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature