Total and extracellular vesicle-bound plasma P-selectin as diagnostic biomarkers for acute deep vein thrombosis.

ABSTRACT:

Background

Plasma P-selectin has shown moderate diagnostic potential for deep vein thrombosis (DVT). In plasma, P-selectin is found in soluble form and bound to extracellular vesicles (EVs). It is unknown whether specific detection of EV-bound P-selectin would improve the diagnostic performance of P-selectin. We aimed to investigate the diagnostic performance of EV-bound and total P-selectin for acute DVT, alone and in combination with D-dimer.

Objectives

We aimed to investigate the diagnostic potential of total extracellular vesicle-bound plasma P-selectin as diagnostic biomarkers for acute deep vein thrombosis in a cohort of patients admitted to hospital with suspected DVT.

Methods

A bead-based flow cytometric assay was developed for selective detection of EV-bound

SUBMITTER: Xavier S 

PROVIDER: S-EPMC12514487 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature