Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues.

ABSTRACT:

Background

Cuproptosis, a newly identified form of cell death, presents an as-yet-unclear potential correlation with Osteoarthritis (OA) pathogenesis. This study aimed to explore the relationship between chondrocyte cuproptosis and OA, and to evaluate the therapeutic potential of the copper ion chelator tetrathiomolybdate (TTM) in OA treatment.

Methods

We collected clinical cartilage samples and animal specimens, employing Micro-CT, histopathological staining, immunohistochemistry, and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to evaluate the potential occurrence of chondrocyte cuproptosis during OA progression. In vitro, we used elesclomol and copper sulfate to create a cuproptosis model in mouse chondrocytes. Techniques like ICP-MS, CCK-8, and others wer

SUBMITTER: Hua H 

PROVIDER: S-EPMC12514526 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature