Correlation between brain structural features and early motor outcomes from deep brain stimulation in patients with Parkinson disease.

ABSTRACT:

Background

Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective neuromodulation therapy for patients with mid-to-late-stage Parkinson disease (PD), demonstrating significant efficacy at the group level. However, therapeutic outcomes across individual patients vary. This study investigated the correlation between brain structural characteristics and the early motor outcomes after administration of bilateral STN-DBS in patients with PD.

Methods

A total of 26 patients with PD were assessed 3-6 months after surgery according to Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score. Patients were stratified into a high-improvement group (HMI; n=19) and a low-improvement group (LMI; n=7) based on a 30% improvement rate. Structural magnetic resonance i

SUBMITTER: Zheng W 

PROVIDER: S-EPMC12514586 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature