Diagnostic performance of ultrasound elastography alone and in combination with conventional ultrasonography for Bethesda III-IV thyroid nodules: a systematic review and meta-analysis.

ABSTRACT:

Background

The current diagnostic paradigm for thyroid nodule characterization predominantly depends on fine needle aspiration (FNA) cytology. Nevertheless, in cases of indeterminate cytology classified as Bethesda III and IV, the clinical community continues to face significant challenges in establishing reliable non-invasive diagnostic modalities for accurate pathological differentiation. This meta-analysis evaluates the diagnostic value of ultrasound elastography in Bethesda III-IV thyroid nodules, and compares the diagnostic efficacy when combined with conventional ultrasound.

Methods

We searched English medical databases, including PubMed, Embase, Web of Science, Cochrane Library, and Ovid, for relevant literature. These studies were reviewed by 2 members who also extra

SUBMITTER: Sun CF 

PROVIDER: S-EPMC12514589 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature