Nomogram based on preoperative contrast-enhanced CT predicts early liver metastasis in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Early liver metastasis (LM) of pancreatic ductal adenocarcinoma (PDAC) is a critical factor affecting curative resection and poor prognosis. However, contrast-enhanced computed tomography (CECT) demonstrates limited sensitivity in detecting early-stage LM from PDAC. We aimed to construct a nomogram from conventional CECT features and preoperative tumor markers for early prediction of LM from PDAC.

Methods

The preoperative tumor markers and CECT images of 184 patients with pathologically confirmed PDAC (from January 2015 to November 2021) were retrospectively analyzed. We compared patients with early and non-early LM from PDAC in terms of CECT features and tumor markers. Finally, multivariate analysis was performed to identify independent risk factors for early LM

SUBMITTER: Duan A 

PROVIDER: S-EPMC12514649 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature