Transcription factors and candidate functional SNPs associated with variation in fatty acid composition from skeletal muscle of pigs.

ABSTRACT: Pork is an essential source of fatty acids (FAs) in the human diet. Fatty acids are important for various biological processes and can impact transcription regulation. The primary objective of this study was to identify candidate functional single nucleotide polymorphisms (SNPs) and expression quantitative trait loci (eQTL) associated with FA composition variation, and transcription factors (TFs) related to lipid metabolism using SNP array genotyping and Longissimus lumborum muscle transcriptome of Large White pigs. A total of 105 378 unique SNPs were identified, including 74 955 originating from RNA-Seq data and 30 423 SNPs from the Porcine 50K SNP chip. These SNPs were tested for association with the skeletal muscle gene expression data (15 090 genes) using the matrixeqtl package. Genome

SUBMITTER: Durval MC 

PROVIDER: S-EPMC12514662 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature