Collateral status correlates with stroke outcomes mediated by early infarct growth rate in patients with acute large vessel occlusion.

ABSTRACT:

Background

Early infarct growth rate (EIGR) and both arterial- and tissue-level collaterals (TLCs) are strongly associated with stroke prognosis, yet the complex interplay among multi-level collateral status, EIGR, and stroke outcomes remains incompletely understood. This study aimed to comprehensively characterize collaterals at the arterial, tissue, and venous outflow (VO) levels, and to delineate the distribution of EIGR among acute stroke patients with varying clinical outcomes.

Methods

Patients with acute large vessel occlusion were retrospectively recruited. Pial arterial collaterals (PACs), TLCs and VO were measured by the modified Tan (mTan) scale, hypoperfusion intensity ratio (HIR), and the cortical vein opacification score (COVES), respectively. EIGR was subsequen

SUBMITTER: Fu J 

PROVIDER: S-EPMC12514663 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature