Using ¹⁸F-ML-10 PET/CT imaging to detect atherosclerosis lesions and apoptotic processes in mice.

ABSTRACT:

Background

Apoptosis plays a critical role in the development and progression of atherosclerotic plaques. [18F] fluoride 2-(5-fluoro-pentyl)-2-methylmalonic acid (¹⁸F-ML-10), a positron emission tomography (PET) radiotracer, selectively targets cells undergoing apoptosis by binding to apoptosis-associated membrane alterations. This study evaluated the efficacy of ¹⁸F-ML-10 PET/computed tomography (CT) in visualizing apoptotic activity in atherosclerotic plaques.

Methods

Apolipoprotein E knockout (ApoE^-/-) mice were fed a high-fat diet to induce atherosclerosis, and imaged at 20 and 32 weeks, with C57BL/6J (C57) mice serving as controls. ¹⁸F-ML-10 was synthesized using a standard conjugation protocol and subsequently used for the in

SUBMITTER: Pang L 

PROVIDER: S-EPMC12514677 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature