Ultrafast ultrasound localization microscopy for differential diagnosis of reactive hyperplasia and metastatic cervical lymph nodes: a pilot study.

ABSTRACT:

Background

Cervical lymph nodes (LNs) play pivotal roles in immune surveillance and oncologic spread. This study investigates the clinical utility of ultrafast ultrasound localization microscopy (ULM) for distinguishing reactive hyperplasia from metastatic cervical LNs, aiming to improve diagnostic precision beyond conventional ultrasound (US) capabilities.

Methods

We prospectively analyzed 135 histopathologically confirmed LNs (scheduled for December 2023 to October 2024) using multimodal US assessment: conventional two-dimensional (2D) imaging, superb microvascular imaging (SMI), and ULM. Quantitative parameters [vessel diameter, vascular index (VI), microvascular density (MVD)] and qualitative flow patterns were systematically evaluated against pathological standards. Dia

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12514697 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature