Evaluation of the perilesional normal-appearing white matter (NAWM) microenvironment in relapsing-remitting multiple sclerosis with quantitative T1rho magnetic resonance imaging.

ABSTRACT:

Background

While conventional magnetic resonance imaging (MRI) in multiple sclerosis (MS) primarily evaluates focal lesions, the normal-appearing white matter (NAWM) encompasses brain tissue that appears radiologically normal but harbors subtle pathological changes that contribute to the overall disease burden. The aim of this study was to investigate the role of T1rho MRI in characterising distance-dependent microstructural changes in the perilesional NAWM in patients with relapsing-remitting multiple sclerosis (RRMS).

Methods

T1rho and diffusion tensor imaging (DTI) images were acquired from 30 patients with RRMS and 30 age-matched healthy controls. A total of 217 non-contrast-enhancing MS lesions were identified, and five perilesional layers were delineated from the lesio

SUBMITTER: Wang L 

PROVIDER: S-EPMC12514733 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature