Correlation between the extracellular volume fraction and hemodynamic parameters in light-chain cardiac amyloidosis patients.

ABSTRACT:

Background

Light-chain cardiac amyloidosis (AL-CA) is a severe disease marked by amyloid protein deposits in cardiac tissues. This study aimed to explore the correlation between extracellular volume fraction (ECV) assessed via cardiac magnetic resonance (CMR) and invasive hemodynamic measurements in AL-CA patients.

Methods

This was a cross-sectional study. All AL-CA patients underwent right heart catheterization to measure hemodynamic parameters and CMR at baseline. Pearson correlation analysis and quantile regression were employed to explore the relationship between the ECV and hemodynamic parameters. Patients were categorized into two groups based on hemodynamic status using hierarchical clustering. The two groups were analyzed as binary outcomes using logistic regression

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12514738 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature