Myelin-water imaging and multi-shell diffusion-weighted imaging in adults with adrenoleukodystrophy.

ABSTRACT: The pathophysiology of X-linked adrenoleukodystrophy (ALD) is not well-understood. New quantitative MRI (qMRI) sequences, such as myelin-water imaging (MWI) and multi-shell diffusion-weighted imaging (DWI), are non-invasive techniques that can investigate microstructural abnormalities in the brain. Using these techniques, this study investigated abnormal white matter of cerebral ALD (cALD) lesions and normal-appearing white matter (NAWM) in ALD and in controls. Adult participants were scanned on 3T MRI scanners. Fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD) were measured with diffusion tensor imaging (DTI). The neurite density index (NDI) was established using neurite orientation dispersion and density imaging (NODDI). Myelin water fractions (MWF) were eval

SUBMITTER: Yska HAF 

PROVIDER: S-EPMC12514751 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature