Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis.

ABSTRACT: Improving the intestinal microenvironment and regulating the intestinal flora are highly important in the treatment of osteoporosis. Although previous studies have shown that oral probiotics can prevent or reverse bone loss, their survival rate and therapeutic effect are greatly reduced when they pass through the gastrointestinal chemical microenvironment, which limits their clinical application. Therefore, improving their survival rate and therapeutic effect is crucial. To address this issue, we formed a metal‒phenolic network (L@Q-Ca) on the surface of Lactobacillus rhamnosus (LR) by combining quercetin and calcium metal ions to enhance its therapeutic effect. To enable the LR to pass successfully pass the gastrointestinal chemical environment, dopamine was polymerized on the surface of

SUBMITTER: Li Z 

PROVIDER: S-EPMC12514797 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature