Cascade-targeting copper homeostasis nano-regulators for mild-photothermal boosted cuproptosis/ferroptosis mediated breast cancer therapy.

ABSTRACT: Inducing cuproptosis in tumor cells is significantly impeded by the challenges of arduous copper ion delivery in vivo and the unbreakable intracellular copper homeostasis, which leads to insufficient mitochondrial copper accumulation. Here, a carrier-free metal-polyphenolic (CF-MPs) based nanoplatform (T-T@Cu) that features tumor-mitochondria cascade-targeting, glutathione (GSH) depletion and near-infrared Ⅱ photothermal performance is designed to induce mitochondria copper-overload and exacerbate cuproptosis in tumor cells. By leveraging the enhanced permeability and retention (EPR) effects and the mitochondria-targeting capabilities of tannic acid, T-T@Cu effectively increases mitochondrial copper accumulation in tumor cells. Upon exposure to a 1064 nm laser, T-T@Cu triggers mild phototh

SUBMITTER: Liang X 

PROVIDER: S-EPMC12514802 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature