Drug loaded cerium oxide nanozymes prevent radiation-Induced cataracts via suppressing the cGAS-STING pathway.

ABSTRACT: Radiation-induced cataracts (RIC), a significant cause of blindness, arise from oxidative damage and inflammation in the lens epithelium, and there has been a lack of effective targeted therapeutic drugs in clinic. Here, we proposed and developed a novel approach for prevention and treatment of RIC via multifunctional nanozymes. We first demonstrated activation of the cGAS-STING pathway can drive mitochondrial oxidative stress and cytosolic double-stranded DNA (dsDNA) accumulation in ionizing radiation (IR)-exposed lens epithelial cells (LECs). Accordingly, a nanozyme-based drug delivery system, namely porous CeO₂ loaded with STING inhibitors H-151 (CeO₂@H-151), was developed for RIC prevention and treatment. Importantly, CeO₂@H-151 nanozymes not only decre

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12514853 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature