Development and evaluation of image preprocessing pipelines for the Centiloid method on Down Syndrome data.

ABSTRACT:

Background

Centiloid provides a standardized process to quantify brain amyloid in which a subject's T1 magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) scans are registered and warped to Montreal Neurological Institute 152 space using prescribed procedures. The method has a high failure rate in Down syndrome (DS) subjects from the Neurodegeneration in Aging Down Syndrome (NiAD) project. We evaluate imaging preprocessing methods (PMs) to improve the DS success rate.

Methods

PMs were constructed from combinations of image origin reset, filtering, MRI bias correction, and MRI skull stripping. Centiloid results were evaluated for adherence to standards using The Global Alzheimer's Association Interactive Network dataset. PMs were also evaluated usi

SUBMITTER: Luo W 

PROVIDER: S-EPMC12514937 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature