APOE ε4 linked effects on clinical features and neuropathology in dementia with Lewy bodies.

ABSTRACT:

Introduction

Apolipoprotein E (APOE) ε4 is a strong genetic risk factor for Alzheimer's disease (AD) neuropathologic changes, but its contribution to clinical features and pathology in dementia with Lewy bodies (DLB) is less clear.

Methods

Using the National Alzheimer Coordinating Center dataset, we investigated APOE ε4-associated effects on DLB core clinical features and neuropathology.

Results

In analyses of APOE ε4 carriers, dosage, and genetic risk score, APOE ε4 was associated with lower odds of fluctuating cognition and parkinsonism and higher odds of visual hallucinations. APOE ε4 was associated with greater neocortical Lewy body pathology, partially mediated by AD co-pathology. The severity of fluctuating cognition was associated with Lewy body pathology stage

SUBMITTER: Ye R 

PROVIDER: S-EPMC12514938 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature