Optimal Variable Flip Angle Schemes for Hyperpolarized MR Kinetic Modeling Robust to RF Field Variations.

ABSTRACT: Hyperpolarized carbon-13 magnetic resonance has enabled the real-time observation of biochemical pathways in living cellular systems. Pharmacokinetic modeling of such experiments provides estimates of conversion rates between metabolites, which, in turn, can be used to distinguish between healthy and diseased tissues, for example. This work focuses on choosing time-varying flip angle schemes that minimize the uncertainty of model parameter estimates by maximizing the Fisher information while taking into account B₁ field strength variation by incorporating an assumed prior distribution. Monte Carlo simulations demonstrated that the optimized variable flip angle (VFA) schemes provided less uncertain model parameter estimates compared to an optimized constant flip angle (CFA) schem

SUBMITTER: Garnæs MF 

PROVIDER: S-EPMC12514949 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature