Integrating Cell Population Data With Hematology Analyzer Messages for Improved Detection of Immature White Blood Cells and Laboratory Efficiency.

ABSTRACT:

Background

Improving efficiency and reducing turnaround time are crucial in clinical laboratories. While automated analyzers such as the Beckman Coulter DxH 900 streamline workflow, subtle abnormalities like blasts and immature granulocytes (IGs) may be missed, especially in the absence of WBC-related suspect messages. This study evaluated whether integrating cell population data (CPD) with instrument messages could enhance detection accuracy.

Methods

A total of 587 blood samples were analyzed and classified with (Group A) or without (Group N) WBC-related suspect messages. Manual slide review (MSR) and digital morphology (DM) served as reference standards. CPD parameters were evaluated using receiver operating characteristic (ROC) analysis and Youden's index to establish opt

SUBMITTER: Hsu LC 

PROVIDER: S-EPMC12514968 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature